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Coronary artery disease: improved reproduc-ibility of calcium scoring with an electron-beam CT vol-umetric method. Since most of the causative mutations in individuals with rare diseases arelocated within the coding regions of the genes or affect positions very close to thesplice sites, WES application seems to have – at the moment – an advantage overWGS, because it goes with a better coverage of the target regions and produces asmaller number of total variants. The procedures are verycommon, and each has its own set of pros and cons

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