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Apparently, thisTreg reducing activity of the P13K/Akt pathway is the result of hyperactivation of thepathway through the combined ligation of the TCR, CD28, and the IL-2R and can play a rolein converting Tregs into autoimmune effector cells. Arsenic tends to accumulate in keratin-rich tissues,and exposure may manifest as discolored bands or Mees’lines in fingernails and toenails. As the balloon grows, itpushes against the blockage, stretching the artery walls open, allowing themuch needed blood supply to flow freely again

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